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776753756
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Neurons SynapticCurrents
11 records
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potentials by distal synaptic stimulation at teh 60% of threshold intensity
for somatic action potential initiation was blocked by application of APV (50
µM). Thus, under physiological conditions, the depolarization at the soma
evoked by distal synaptic stimulation (Fig. 6E) did not represent a passively
attenuated PSP. More likely, it reflected a PSP which was amplified in the
distal dendrite by a local Ca2+ action potential. As a consequence, the
[Ca2+]i transient in distal dendrites, evoked by synaptic stimulation which
remained subthreshold at the soma and which was sensitive to APV, represented
primarily Ca2+ inflow via dendritic voltage-dependent Ca2+ channels."p.611
