Referring records
There are no records that refer to this one.
Contents
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ID Neurons
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-990651240
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ID Methods Electrophysiology
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663618204
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Synapse type
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mGluR1a
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Peak conductance
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-
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Peak current
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-
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Peak potential
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18.4 mV
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E rev
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-
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Latency
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-
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Citations
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"In the presence of tetrodotoxin (TTX; 2 µM) to block spikes, ACPD depolarized
LTS cells by an average of 18.4 mV (n = 9)."p.904
"DHPG (100-200 µM), a specific group I mGluR agonist, caused ACPD-like effects
in all tested cells (3 pairs of FS/RS cells; 1 of 2 LTS cells in TTX). The
selective mGluR1a antagonist LY367385 (30-200 µM) prevented ACPD-iduced
spiking and oscillations in 8 LTS cells. ... We conclude that the
synchronizing effects of ACPD are mediated via mGluR1a on LTS cells".
Pp.906-907
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Reference figures
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Reference text
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pp.906-907
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Comments
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-
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Methods Electrophysiology.ID Ref.
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663618204
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Neurons.ID Ref.
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-990651240
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ID Neurons
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-990651240
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ID Methods Electrophysiology
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976202835
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Synapse type
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mAChR
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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"Muscarine (50 µM) indeed depolarized LTS cells and caused some spiking, but
was less potent than APCD and usually did not induce clear synchrony in normal
medium. However, when the bath K+ concentration was raised to 6 mM, 50 µM
muscarin induced LTS spiking, subthreshold fluctuations and synchrony similar
to that evoked by APCD (n = 2 LTS-LTS pairs). The antagonist pinrezepine (5-10
µM) blocked muscarinic effects on LTS cells (n = 2) and muscarine-induced
rhytmic IPSPs (n = 4 FS cells), suggesting they were mediated by M1/M4
receptors."p.907
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Reference figures
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Fig. 5
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Reference text
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p.907
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Comments
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-
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Methods Electrophysiology.ID Ref.
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976202835
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Neurons.ID Ref.
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-990651240
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ID Neurons
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-452045127
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ID Methods Electrophysiology
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663618204
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Synapse type
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GABA
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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"Indeed simultaneous recordings showed that each burst of spikes in an LTS cell
was coincident with a cluster of IPSPs in a neighbouring FS cell (Fig.
4a)."p.906
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Reference figures
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Fig. 4
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Reference text
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p.906
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Comments
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-
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Methods Electrophysiology.ID Ref.
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663618204
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Neurons.ID Ref.
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-452045127
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ID Neurons
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-381558745
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ID Methods Electrophysiology
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655797886
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Synapse type
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sEPSP
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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"The time course of sEPSPs generated by apical current injection recorded at
source and after propagation to the soma were distinct and demonstrated a
characteristic crossing during the decaying phase (Fig. 2A)..."
"Under control conditions we observed that sEPSPs did not appreciably summate
when generated from any recording location (Fig. 3, A and B), with the
integral of sEPSPs increasing marginally as the site of sEPSP generation was
more distal (3.8 µV*s/100 µm; Fig. 3B)
"The half width of somatically and dendritically generated sEPSPs recorded at
the soma were similar regardless of the site of sEPSP generation (n = 38; Fig.
2, B and C)."
"The 20-80% rise time of sEPSPs at the soma, however, increased as the site of
generation was more distal (Fig.2D).
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Reference figures
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Fig.2-3
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Reference text
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p.3179-3181
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Comments
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-
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Methods Electrophysiology.ID Ref.
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655797886
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Neurons.ID Ref.
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-381558745
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ID Neurons
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-225112611
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ID Methods Electrophysiology
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39353653
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Synapse type
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PSP
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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6.3+-0.98 ms
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Citations
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"The whisker evoked responses consisted of an initial EPSP with short latency
(5-7 ms) followed by several PSPs over the subsequent 100-800 ms. The
whisker-evoked responses included both EPSP and IPSP components. IPSPs
typically had very small amplitudes near resting potential but were
significantly larger when the cells were depolarized. Figure 5 shows examples
of whisker-evoked responses (averaged from multiple trials) in an RS cell, and
FS cell, an IB cell and a dendrite."pp.1174-75.
"Latency was correlated with the neurons' subpial depth. As shown in Fig.11,
cells located 500-700 µm below the pia had the shortest latencies for the
primary EPSP. Cells more superficial than this had intermediate latencies, and
cells >700µ m had the longest latencies. The latency of the initial EPSP was
not correlated with the cell type, and relatively short- and long-latency
initial EPSPs were found in RS, FS, and IB cells and dendrites."p.1176.
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Reference figures
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Fig.5
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Reference text
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pp.1174-1175
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Comments
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More information on receptive fields, responses to primary and lower order
whiskers on pp.1175-76 and Figs´. 8-11
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Methods Electrophysiology.ID Ref.
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39353653
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Neurons.ID Ref.
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-225112611
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ID Neurons
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-225112611
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ID Methods Electrophysiology
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1722334649
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Synapse type
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EPSP
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Peak conductance
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-
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Peak current
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-
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Peak potential
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1.5 to 12.5 mV
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E rev
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-
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Latency
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-
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Citations
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"All cell types displayed spontaneous synaptic activity. The mean frequency of
spontaneous events was generally higher in neurons of the middle layers (~4-8
Hz) than in those of superficial and deep layers (~0.5-4 Hz) (Fig. 4A).
Spontaneous events included both EPSPs and IPSPs. The peak EPSP amplitudes
ranged <=20 mV, with mean amplitudes in individual cells ranging from 1.5 to
12.5 mV. The mean EPSP amplitude were generally larger in superficial layer
cells than in deeper layer cells (Fig. 4B).
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Reference figures
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Fig.4
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Reference text
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p.1174
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Comments
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-
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Methods Electrophysiology.ID Ref.
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1722334649
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Neurons.ID Ref.
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-225112611
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ID Neurons
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-225112611
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ID Methods Electrophysiology
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1722334649
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Synapse type
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IPSP
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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"Spontaneous IPSPs were typically very small at the resting membrane potential
but became clearly evident when the membrane was depolarized with injected
current."p.1174.
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Reference figures
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-
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Reference text
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p.1174
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Comments
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-
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Methods Electrophysiology.ID Ref.
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1722334649
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Neurons.ID Ref.
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-225112611
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ID Neurons
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-156273530
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ID Methods Electrophysiology
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663618204
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Synapse type
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GABA
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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"Indeed simultaneous recordings showed that each burst of spikes in an LTS cell
was coincident with a cluster of IPSPs in a neighbouring FS cell (Fig. 4a).
Similar clusters of IPSPs were observed in about 70% of all FS and RS cells
recorded in APCD"p.906
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Reference figures
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Fig. 4
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Reference text
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p.906
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Comments
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-
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Methods Electrophysiology.ID Ref.
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663618204
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Neurons.ID Ref.
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-156273530
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ID Neurons
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776753756
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ID Methods Electrophysiology
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-847634651
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Synapse type
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NMDA/AMPA
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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"Figure 6E and F illustrates that the initiation of dendritc regenerative
potentials by distal synaptic stimulation at teh 60% of threshold intensity
for somatic action potential initiation was blocked by application of APV (50
µM). Thus, under physiological conditions, the depolarization at the soma
evoked by distal synaptic stimulation (Fig. 6E) did not represent a passively
attenuated PSP. More likely, it reflected a PSP which was amplified in the
distal dendrite by a local Ca2+ action potential. As a consequence, the
[Ca2+]i transient in distal dendrites, evoked by synaptic stimulation which
remained subthreshold at the soma and which was sensitive to APV, represented
primarily Ca2+ inflow via dendritic voltage-dependent Ca2+ channels."p.611
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Reference figures
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Fig. 6
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Reference text
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p.611
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Comments
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-
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Methods Electrophysiology.ID Ref.
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-847634651
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Neurons.ID Ref.
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776753756
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ID Neurons
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1000126375
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ID Methods Electrophysiology
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-847634651
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Synapse type
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AMPAR
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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-
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Reference figures
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Fig. 6
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Reference text
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p.611
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Comments
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Present and blocked by CNQX.
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Methods Electrophysiology.ID Ref.
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-847634651
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Neurons.ID Ref.
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1000126375
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ID Neurons
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1000126375
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ID Methods Electrophysiology
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-847634651
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Synapse type
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NMDAR
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Peak conductance
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-
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Peak current
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-
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Peak potential
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-
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E rev
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-
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Latency
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-
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Citations
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-
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Reference figures
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Fig. 6
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Reference text
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p.611
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Comments
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Present and blocked by APV.
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Methods Electrophysiology.ID Ref.
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-847634651
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Neurons.ID Ref.
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1000126375
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37 records