| CoCoDatCat 041008 > Folder > Neurons IonicCurrents > 481039627 |
|
||||||
|---|---|---|---|---|---|---|
| ID Neurons | 481039627 | |||||
| ID Methods Electrophysiology | -1020917390 | |||||
| Current name | I(NaP) | |||||
| Charge carrier | Na+ | |||||
| Peak conductance | - | |||||
| Peak current | (Fig. 2) | |||||
| E rev | - | |||||
| V threshold | about -60 mV | |||||
| V half activation | - | |||||
| V peak | -40 to - 35 mV | |||||
| Citations |
"As has also been found for the fast INa during development (Huguenard et al. 1988), the voltage dependence of INaP activation did not change during the time frame of out study. However, INaP seemed to increase in magnitude during development (Fig. 1A)." "As shown in the histogram of Fig. 2A, the strongest increase in INaP amplitude ocurred between aoung and juvenile rats where the mean peak INaP amplitude more than doubled, whereas a smaller increase was seen from juvenile to mature rats." "Surprisingly, only a rather weak correlation (r=0.61)was found between age amd maximal current density." |
|||||
| Reference figures | Fig. 1, 2. | |||||
| Reference text | pp.291-292 | |||||
| Comments | Persistent sodium current was completely blocked by TTX. | |||||
|
Methods Electrophysiology.ID Ref. | -1020917390 | ||||
|
Neurons.ID Ref. | 481039627 | ||||