-806603121 Neurons IonicCurrents 68 records
	ID Neurons	-806603121
	ID Methods Electrophysiology	974903425
	Current name	Low-threshold Ca
	Charge carrier	Ca2+
	Peak conductance	-
	Peak current	-
	E rev	-
	V threshold	-
	V half activation	-
	V peak	-
	Citations	"Table I lists the responses of currents to application of divalent ions and organic compounds. The high-threshold currents were more sensitive than the low-threshold currents to block by Cd2+, while the reverse was true for Ni2+. Replacement of external Ca2+ by Ba2+ incresed the maximum high-threshold current and shifted it it approximately 10 mV to the left on the I-V curve. The low-threshold current was reduced in Ba2+. Nimodipine (Sigma) supressed both the low-threshold and the high-threshold currents (Fig.2A). Racemic BAY K 8644 (Miles Labs.) had an agonist effect which was most pronounced at command potentials negative to the maximum of the I-V curve (e.g. Fig. 2B). The increase at the point of maximum inward current was smaller and more variable (mean 16%), and the current was reduced at positive potentials. There was no consistent effect on the low-threshold current. Omega-Conotoxin GVIA (Peninsula Labs.) reduced the high-threshold current only (Fig. 2C). Nimodipine and omega-conotoxin attenuated the currents without any voltage shift in the I-V curves. The effects of all substances were reversed by washing, except for omega-conotoxin, from which there was only a slight recovery".pp.176-177.
	Reference figures	Table 1, Fig. 2
	Reference text	p.177
	Comments	Authors claim similarity to T-current (p.177).
	Methods Electrophysiology.ID Ref.	974903425
	Neurons.ID Ref.	-806603121

Referring records

There are no records that refer to this one.