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1006790213
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Neurons IonicConductances
51 records
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when the voltage was stepped to 40 mV above the resting membrane potential
(Fig. 10A) was observed. Burst duration increased while the intra-burst closed
time decreased as a function of the applied voltage (Fig. 10A). The unitary
conductance of this channel was 16 +- 1 pS (Fig.10B, n = 4). A long closed
duration was observed in most traces when voltage steps of 5s to +60 mV above
the resting membrane potential were applied (Fig. 10C). Summation of 45 sweeps
revealed a slowly inactivating ensemble current (Fig. 10C). The decay of the
ensemble current was best fitted to a single exponent with a time constant of
5.5 +- 2 s at +60 mV above the resting membrane potential (n = 3). This time
constant was similar to the slow time constant of the macroscopic current in
nucleated patches zero mV (3.5 +- 0.8 ms, n = 6, Fig. 8)."p.632
