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1064194824
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Neurons FiringProperties
65 records
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different from dendritic depolarizing currents, even when persistent gNa was
blocked (Fig. 4). As the current increased, rhytmic firing - which started as
single isolated spikes - became associated with spike doublets, and brief
bursts, with interburst frequencies at ~20 to ~40 Hz, and within-burst spike
intervals ~5 ms (1.1 nA) to ~4-4.5 ms (1.5 ms)....Still larger depolarizing
currents produced high-frequency tonic firing. The overall pattern of behavior
is similar to that reported by Steriade et al. (1998). [See also Fig. 3.7 in
Steriade (2001) ]."p.913
"The model neuron in Fig. 5 had no persistant gNa and gKC was large. This cell
fired rhytmic single spikes over the range of somatic current injections 0.15
to 1.05 nA; fiting frequency increased approximately linearly with current
amplitude. For larger current injections, however, the model neuron started to
fire spike doublets. A 2-s simulation was also run (not shown) in which the
injected current was ramped slowly from 0.75 to 1.35 nA. Rhytmic single spikes
switched to single-spike/spike-doublet pairs at about 1.1 nA, which again
switched to just rhytmic doublets at about 1.2 nA."pp.913-914
