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-2140593619
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Neurons FiringProperties
65 records
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the summed depolarization of the composite PSP and the attenuated dendritic
CA2+ action potential. Under these conditions , the somatic action potential
followed the dendritic action potential (Fig. 7A). The time of occurence of
the synaptically evoked dendritic action potential with respect to the somatic
action potential was dependent on activation of NMDAR channels. Addition of
APV (50 µM) eliminated initiation of a distal dendritic Ca2+ action potential
and only a somatic action potential was initiated which back-propagated into
the distal apical dendrite (Fig. 7B). Ca2+ action potentials initiated by
dendritic current injection also spread, strongly attenuated, to the soma and
if the somatic depolarization was of sufficient amplitude it could initiate
Na+ action potentials, presumably originating in the axon (see Stuart et al.
1997), which back-propagated into the distal dendrite (Fig. 7C). Thus, the
initiation site controlling the impulse output of the neuron remained in the
axo-somatic region (see also Stuart et al. 1997)."p.611
