|
SSC90
|
Literature
38 records
|
sensorimotor cortex.
cortex of 14 to 28-day-old rats. Whole cell voltage clamp revealed a slowly
inactivating high-threshold Ca2+ current, activated positive to -45 mV, and a
transient low-threshold Ca2+ current, activated positive to -65 mV. The
high-threshold current was more sensitive to block by Cd2+ and the
low-threshold current was more sensitive to block by Ni2+. Replacement of Ca2+
by Ba2+ increased the high-threshold current and reduced the low-threshold
current. The high-threshold current was enhanced by Bay K 8644 and reduced by
nimodipine and omega-conotoxin. The low-threshold current was also reduced by
nimodipine but was insensitive to Bay K 8644 and omega-conotoxin. The
properties of the currents were consistent with different underlying Ca2+
channel types.
