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HHP91
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Literature
38 records
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cerebral cortex
classes, referred to as pyramidal and nonpyramidal (stellate) cells, which
correspond to functional classes of projection neurons and local circuit
interneurons, respectively. In this study, we demonstrate that specific
morphological, immunohistochemical, and physiological features, that allow
class distinction of neurons in situ, are retained in acutely isolated
neocortical neurons. Furthermore, voltage-clamp analysis with patch-clamp
techniques indicate the differences in functional properties in adult neurons,
reflect cell-specific, developmental changes in the density and type of
specific classes of Na+, K+ and Ca2+ channels expressed. The differences in
channel properties contribute to the different input-output relations of
neocortical neurons, which enable inhibitory neurons to follow excitatory
inputs faithfully and projection neurons to have more integrative roles.
