H96 Literature 38 records
	ID	H96
	Title	Low-threshold calcium currents in central nervous system neurons.
	Year	1996
	Journal Chapter Book	J
	Abstract	The low-threshold calcium current, or T current, has recently been demonstrated with voltage-clamp recordings in a variety of central nervous system (CNS) neurons. It is especially prominent in the soma and dendrites of neurons with robust calcium-dependent burst firing behaviors such as thalamic relay neurons and cerebellar Purkinje cells. Single-channel and macroscopic current behavior have been carefully investigated and kinetic schemes devised to completely describe the activation and inactivation processes. The kinetic properties of T current lead to activation of low-threshold spikes subsequent to transient membrane hyperpolarizations. Putative functional roles for T current include generation of low-threshold spikes that lead to burst firing, promotion of intrinsic oscillatory behavior, boosting of calcium entry, and synaptic potentiation.
	IonicCurrents	y
	IonicConductances	y
	SynapticCurrents	n
	Connectivity	n
	Morphology	n
	FiringProperties	n
	PhysicalCopy
	Comments	DATA NOT ENTERED: Comparative review on biophysical properties, pharmacology, localization and function of T-type calcium current. Very few data from neocortical preparations.
	dbCollator	JDJ
	URL
	Gen Abstract	0
	dbCollators.Initials Ref.	JDJ
	Literature Books.ID Literature Ref.
	BrainMaps.ID Ref.
	Literature BookChapters.ID Literature Ref.
	Literature JournalArticles.ID Literature Ref.	H96
	Literature LinkTable.ID Literature Ref.	H96
	Methods Electrophysiology.ID Literature Ref.
	Neurons.ID Literature Ref.

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